Samant Lab Publications

(* = equal contribution; @ = corresponding author(s))

Peer-reviewed articles

Native size-exclusion chromatography–based mass spectrometry (SEC-MS) reveals new components of the early Heat Shock Protein 90 inhibition response among limited global changes.

Samant RS*@, Batista SA*, Larance M, Ozer B, Milton CI, Bludau I, Wu E, Biggins L, Andrews S, Hervieu A, Johnston HE, Al-Lazikhani B, Lamond AI, Clarke PA, Workman P@. Mol Cell Proteomics 2022 (in press)
 10.1016/j.mcpro.2022.100485 | PDF | PubMed | pre-print | web-resource | PRIDE dataset

Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads.

Johnston HE@, Yadav K, Kirkpatrick JM, Biggs GS, Oxley D, Kramer HB, Samant RS@. Anal Chem 2022; 94: 10320–8
10.1021/acs.analchem.1c04200 | PDF | PubMed | pre-print | PRIDE: dataset 1 | PRIDE: dataset 2 | PRIDE: dataset 3 | GenEngNews


Reviews

Alternative systems for misfolded protein clearance: life beyond the proteasome.

Johnston HE, Samant RS@. FEBS J 2020; 15: 4464–87
10.1111/febs.15617 | PDF | PubMed


Book chapters

Al-Mufti Y*, Cranwell S*, Samant RS@. Molecular, Cellular, and Metabolic Fundamentals of Human Aging 2022; Chapter 4: 55–103
10.1016/B978-0-323-91617-2.00004-3|


Rahul’s earlier work

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns.

Collier MP, Betancourt-Moreira K, Li KH, Chen YC, Itzhak D, Samant R, Leitner A, Burlingame A, Frydman J@. Sci Rep 2021; 11: 13084
10.1038/s41598-021-91086-6 | PDF | PubMed

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.

Samant RS, Masto VB, Frydman J@. Genes Dev 2019; 33: 1027–30
10.1101/gad.329383.119 | PDF | PubMed

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae.

Samant RS@, Frydman J@. Methods Enzymol 2019; 619: 27–45
10.1016/bs.mie.2018.12.039 | PubMed |

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.

Samant RS, Livingston CM, Sontag EM, Frydman J@. Nature 2018; 563: 407–11
10.1038/s41586-018-0678-x | PubMed | PRIDE dataset |

Mechanisms and functions of spatial protein quality control.

Sontag EM*, Samant RS*, Frydman J@. Annu Rev Biochem 2017; 86: 33.1–33.26
10.1146/annurev-biochem-060815-014616 | PubMed |

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, et al. Nat Chem Biol 2015; 11: 973–80
10.1038/nchembio.1952 | PDF | PubMed | ScienceDaily | EurekaAlert | MedicalExpress | CardiffUniversity | icr 2016 highlights

E3 ubiquitin ligase CUL5 modulates multiple molecular and cellular responses to HSP90 inhibition in human colon cancer cells.

Samant RS, Clarke PA, Workman P@. Proc Natl Acad Sci USA 2014; 111: 6834–9
10.1073/pnas.1322412111 | PDF | PubMed | ScienceDaily | EurekaAlert | MedicalExpress | PennyWarren | HuffPost | icr 2014 highlights

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Polier S, Samant RS, Clarke PA, Workman P@, Prodromou C, Pearl LH@. Nat Chem Biol 2013; 9: 307–12
10.1038/nchembio.1212 | PubMed | commentary | MedicalNewsToday | icr 2013 highlights |

Molecular biology: choose your protein partners.

Samant RS, Workman P@. Nature 2012; 490: 351–2
10.1038/490351a | PubMed |

The expanding proteome of HSP90.

Samant RS, Clarke PA, Workman P@. Cell Cycle 2012; 11: 1301–12
10.4161/cc.19722 | PDF | PubMed