Decoding ubiquitin chain signals in physiologic and stressed states

Although Lys48-linked ubiquitin is the canonical signal for protein clearance by the proteasome, ‘alternative’ ubiquitin signals play critical yet poorly-characterised roles in misfolded protein clearance—especially under acute stress. Using linkage-specific ubiquitin probes and perturbation tools, we are uncovering how these additional ubiquitin signalling events maintain proteome robustness in a range of physiologic and stressed cellular contexts.

Current projects on ubiquitin signalling include:

Specific ubiquitin linkages in misfolded protein trafficking & stress resilience

• Project Lead: Gaurav Barve
• Collaborators: Yogesh Kulathu; Helle Ulrich; Andrew Frey

Changes in the ubiquitylation landscape with healthy ageing

• Project Leads: Gaurav Barve; Harvey Johnston
• Co-PI: Della David
• Collaborators: Ben Miller; Clive D’Santos; Matthias Trost